Two sample MR report
KANSL1-AS1_Dendritic Cell (DC) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 36 | 0.0085986 | 0.0344175 | 0.8042214 |
| Weighted median | 36 | 0.0227834 | 0.0036895 | 0.0000000 |
| Inverse variance weighted | 36 | 0.0191698 | 0.0027729 | 0.0000000 |
| Simple mode | 36 | 0.0233129 | 0.0070104 | 0.0020807 |
| Weighted mode | 36 | 0.0230803 | 0.0068256 | 0.0017864 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 18.83883 | 34 | 0.9835069 |
| Inverse variance weighted | 18.93379 | 35 | 0.9877293 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0091468 | 0.029683 | 0.7598491 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003417 | 0 | TRUE | 0.0799649 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
